Monday, 16th October International Peptide Symposium 2023

• Macrocyclic peptides with better membrane permeability - Hiroaki Suga
• Hydrazide-based methodology for chemical protein synthesis - Lei Liu
• Furan- and Triazolinedione-based Chemistries for Bio-orthogonal Protein Modification - Annemieke Madder
• Copper-assisted sequence-specific chemical protein conjugation - Bobo Dang
• Building the infinite loop for machine learning guided discovery, delivery, and rapid manufacturing of potential medicines - Brad Pentelute

• Late-Stage Traceless C–H Functionalisation of Peptides - Craig Hutton
• Peptide chemical engineering: from substrate-derived inhibitors to bioconjugation techniques - Alesia A. Tietze
• Total Chemical Synthesis of Glycosylated VEGF-A and evaluation of an optimal sugar for bioactivity  - Paul WR Harris
• Semi-synthesis of homogeneous glycoproteins via novel expressed peptide thioesterification methods - Yasuhiro Kajihara
• A Radical Approach to the Site-Selective Modification of Peptides and Proteins - Nicholas J. Mitchell
• Build it to understand it: O-GlcNAc modification plays multiple protective roles against protein amyloid aggregation and pathogenesis. - Matthew Pratt

• Peptide design through machine learning - Colin J Jackson
• Structure prediction of cyclic peptides via molecular dynamics and machine learning - Yu-Shan Lin
• Cyclic peptides for detection, prevention and treatment of infection - Ulf Göransson
• De novo design of peptides that form transmembrane barrel pores killing antibiotic resistant bacteria - Robert Vacha
• Unravelling the mechanism of lactofungin, a peptide that shows potent synergy with the antifungal drug amphotericin B - Evelyne Deplazes
• A survey of antimicrobial peptides from the global microbiome - Luis Pedro Coelho

What’s New in 2023 for Separation and Mass Spectrometry for peptide research from Thermo Fisher Scientific.
Dr Jose Barreto

The Orbitrap Astral Mass Spectrometer ‘A New Paradigm in detection and analysis’
Dr Bruno Madio

• In cellulo library-derived peptide-based inhibitors of alpha-synuclein aggregation and toxicity - Jody Mason
• TDP-43: At the intersection of chemical biology and structural biology - May Khanna
• Tangling with tau: β-Arch proteomimetics as modulators of amyloid propagation - Juan R Del Valle
• Phosphorylation at different sites changes amyloid fibril structure and pathological properties of α-synuclein - Yan-Mei Li

• Application of chemical tools to accelerate development of protease-targeted therapeutics - Laura E Edgington-Mitchell
• Peptide tools for the investigation of mitochondrial sirtuin 5 - Christian Adam Olsen
• Cyclic peptides that target telomere maintenance in ALT-positive cancers - Yu Heng Lau
• Molecular Repair of Peptide Therapeutics - Krishna Kumar

• Magnetic resonance-guided focused ultrasound: potential for peptide and protein delivery across the blood-brain barrier - Gregg Fields
• Self-Assembly of Cell-Penetrating Lipo-Peptides: Nanostructures as Drug-Delivery Vehicles - Beatriz G. de la Torre
• Improving Membrane Permeation in the Beyond Rule-of-Five Space by Using Prodrugs to Mask Hydrogen Bond Donors - Nicholas Barlow
• Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides - Shiroh Futaki
• Development of gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders - Bernhard Jandl
• Peptide DRT-017 prevents cognitive impairment associated to medical cannabis pain management - Maria Gallo
• Cell-surface retained cell-penetrating peptide additives - Jan Vincent V. Arafiles
• Assessing the cellular permeability of peptidic macrocycles in high-throughput   - Christian Bech-Bartling
• Re-engineering bacterial weapons for peptide delivery into tissue - Jason J Paxman

• Fluorinated amino acids for probing direct contacts by ¹⁹F-NMR - Gottfried Otting
• Exploiting Disulfide-Rich Peptides as Allosteric Probes in the Deconstruction of Ion Channels - Mehdi Mobli
• Structural analysis of an Asterias rubens peptide indicates the presence of a disulfide directed β-hairpin - Norelle Daly
• Pigment Reporters to Optimise Biosynthetic Protein Expression in Cell Free Systems - Constance B Bailey
• Tuning electrostatic and hydrophobic surfaces of aromatic rings to enhance membrane association and cell uptake of peptides - Huy Hoang
• Tunable Electrochemical Peptide Modifications - Dhanya Karipal Padinjare Veedu
• Production of an edible drug for multiple sclerosis treatment in tomato fruit - Linh T.T. Nguyen
• Characterising the cell membrane composition to develop new peptide therapeutics. - Aurelie H Benfield
• Biosynthesis of bicyclic depsipeptide histone deacetylase inhibitors - Xinyun Jian

Explore the vibrant city and enjoy some of Brisbane's local hospitality.

includes Rapid Fire Poster Presentations

• Development of gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders - Bernhard Jandl
• Peptide DRT-017 prevents cognitive impairment associated to medical cannabis pain management - Maria Gallo
• Cell-surface retained cell-penetrating peptide additives - Jan Vincent V. Arafiles
• Assessing the cellular permeability of peptidic macrocycles in high-throughput   - Christian Bech-Bartling
• Re-engineering bacterial weapons for peptide delivery into tissue - Jason J Paxman

• Tuning electrostatic and hydrophobic surfaces of aromatic rings to enhance membrane association and cell uptake of peptides - Huy Hoang
• Tunable Electrochemical Peptide Modifications - Dhanya Karipal Padinjare Veedu
• Production of an edible drug for multiple sclerosis treatment in tomato fruit - Linh T.T. Nguyen
• Characterising the cell membrane composition to develop new peptide therapeutics. - Aurelie H Benfield
• Biosynthesis of bicyclic depsipeptide histone deacetylase inhibitors - Xinyun Jian

• Non-canonical amino acids as NMR probes to locate binding sites of ligands on large proteins - Kasuni B Ekanayake
• Understanding the SAR of a Novel Broad-Spectrum Antifungal - Jun Xuan Ang
• Genetic Encoding of 7-Aza-L-Tryptophan: Isoelectronic Substitution of a Single CH-Group in a Protein for a Nitrogen Atom - Elwy H. Abdelkader
• Ionic Liquid-Mediated Approach for the Synthesis of Site-Specific Thioether Conjugates - Helal Abujubara
• The Structural and Functional Role of Post-translational Modification in Mu Conotoxins - Victoria Adegoke
• Harnessing the Power of Photoinitiated Thiol–ene “click” Reaction for the Efficient Synthesis of S-Lipidated Collagen Model Peptide Amphiphiles - C.J. Aguilar
• Electrochemically enabled peptide backbone modifications - Saurabh Kumar Ahirwar
• Radiolabelled peptides targeting CXCR4 for cancer imaging and treatment - Abdullah F Alosaimi
• Cell penetrating peptides for the delivery of ASOs to the neural retina across rodents and NHPs  - Mark Anastasas
• Unveiling the nemertides: Uncovering novel peptide toxin families in ribbon worms, targeting VGSCs. - Håkan Andersson
• Synthesis of Sulfated Peptides Derived from Evasin Proteins from Ticks reveals Unique Biomimetic Binding to Chemokines - Anthony Ayoub
• Functionalised Peptides Show Absorption in the Stomach and Small Intestine and Potential Lymphatic Uptake - Sanjeevini Babu Reddiar
• From Hue to Health: Exploring Bioactive Peptides in Coloured Barley - Mahya Bahmani
• Integrated design of PLK1 modulatory peptide for cancer therapy - Tabassum Khair Miss Barbhuiya
• Natural product modulators of ClpC1 with overlapping binding sites have different impacts on the Mycobacterium tuberculosis proteome. - Isabel Barter
• Mechanically Interlocked Peptides via Passive-Metal Templation - Hayden J Bell
• Mimicking non-ribosomal peptides from the marine actinomycete streptomyces sp. H-KF8 lead to antimicrobial peptides - Luisa Beyer
• How do insect larvae survive on a plastic diet? A proteogenomics study - Utpal Bose
• A novel chemical approach for the site-specific cyclization of phage-displayed peptides - Libby Brown
• Understanding, intervening and tuning post-translational regulation of T cell immunoreceptors via chemical protein synthesis - Yihui Cao
• Development of Macrocyclic Peptide Inhibitors of Mycobacterium tuberculosis MurF by mRNA Display with Genetic Reprogramming - Patrick Carlos
• In vitro and in vivo studies of topoisomers of a snake venom-derived peptide with anti-infective and antitumoral activity - Adam Carrera
• Lasso grafted Cyclic Peptide Inhibitors of Coagulation Proteases as potential novel therapeutic leads - Liam Cavley
• Modelling peptide-receptor association using parallel cascade molecular dynamics simulations - David Chalmers
• Structural insights into the mechanism of peptide bivalency - Theo Crawford
• Bradykinin Receptor Inhibition Reduces Retinal Permeability in Rat Laser CNV Model - James Daniel
• Synergistic n→π* and n_N→π*_Ar Interaction in Controlling Polyproline Conformation with C-terminus Modification - Paramesh Das
• Biocompatible head-to-side chain peptide macrocyclisation using oxime ligation - Lani J Davies
• Deploying iminium chemistry for access to novel constrained residues: Opioid ligands as a case study - Jolien De Neve
• Structure-based drug design of macrocyclic peptides against neurotensin receptor 1 - Lazarus Andrew de Zhang
• Design and synthesis of peptide ligands targeting C5a receptor 2 - Joshua Dent
• Semisynthesis of mycobacterial lipoproteins - Joshua Dilly
• Bioinspired rapid non-ribosomal peptide macrocyclization - Yaoyu Ding
• Peptide Neurotoxins from Stinging Nettle ‘Venom’ - Thomas Durek
• The Development of Multifunctional Oligonucleotide Conjugates Using Native Chemical Ligation - Daniel Engelhardt
• Cyclic Peptide Inhibitors of Factor XIIα for the Treatment of Thrombotic Disease - Dan Ford
• Total Synthesis of Rufomycins - Bryton Forster
• Constitutive activity of the ghrelin receptor provides a dominant second-messenger switch to re-code dopamine D2 receptor output required for co-ordination of voluntary defecation. - Sebastian G.B. Furness
• Creation of enveloped viral replica equipped with spike protein derived from SARS-CoV-2 - Hiroto Furukawa
• Peptide-drug conjugates as a novel approach to antimalarial therapeutics - Caitlin L Gare
• Investigating the Biosynthesis of the Antimicrobial Peptide Lexapeptide. - Emily Grant-Mackie
• A 'Natural' Electrophilic Solution to Calm the Platelet Temper - Ivy Guan
• Improving oral bioavailability of therapeutic peptides - Giuseppina Guida
• Molecular grafting can generate bioactivities within the cyclic peptide PDP-23 - Fatemeh H. Alipour
• Development of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 - Kat Harrison
• Development of oxidant free methodology for preparing N-glyoxylyl peptide and its apprications - Junya Hayashi
• Synthesis of covalent peptide inhibitors for CHIKV nsP2pro - Junming He
• First in class stabilized peptide inhibitors of human prolyl oligopeptidase - Roland Hellinger
• Insights into Activation of the C3a Receptor Through β-arrestin2 Selectivity and G Protein Specificity - Rachel Heng
• Development of one-pot/stepwise disulfide bond-forming reaction enabled by S-protected cysteine sulfoxide with its application to synthesis of insulin and its lipidated analogue - Kota Hidaka
• Modifying a hydroxyl patch in glucagon like peptide 1 produces biased agonists with unique signaling profiles - Timothy A Hill
• Design, Synthesis and evaluation of highly selective AT2R Agonists. - Baydaa Seezar Hirmiz
• Evaluation of Anti-Pancreatic Cancer Activities of DNA-Alkylating Peptides Specific for RUNX-Binding Sequence - Yuki Hirose
• Improvement in neutrophil recruitment and phagocytosis of resistant Staphylococcus aureus treated with antibiotic-chemoattractants - Winfrey PY Hoo
• Advancing gene cluster manipulation to harness epoxyketone-containing nonribosomal peptides biosynthesis - Chuan Huang
• Discovery of novel RaPID-derived macrocyclic peptide for blockade of the CD24-Siglec-10 interaction as a potential immune checkpoint inhibitor - Wei-En Huang
• Reactivation of the p53 pathway in cancer cells using a grafted cyclotide - Yen-Hua Crystal Huang
• Modifying Pasireotide Analogs for Improved Oral Delivery - Celine Hung
• Cyclic lipidated peptide inhibitors for cardiac endothelium targeting based on the C-terminal tail of Connexin43 - Debora Iaculli
• Design and synthesis of glycopeptides to examine the deglycosylating enzyme activities - Haruka Inoue
• Preparation and Immunological Evaluation of Nanoparticulate Self-adjuvanting Peptide Vaccines as  Breast Cancer Vaccine Candidates - Keita Ito
• Recombinant synthesis of human trefoil factor family 2 (hTFF2) protein - Kirtikumar B. Jadhav
• Development of gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders - Bernhard Jandl
• Development of venom-derived peptides as gut-specific therapeutics to target mucosal biofilms in patients with gastrointestinal disorders   - Bernhard Jandl
• Phage display identified Sertoli and Leydig cell homing peptides for drug delivery to testis - Yugandhara Jirwankar
• Hierarchical Self-Assembly of Peptoid Incorporated Collagen-Mimetic Peptides - Debajit Kalita
• Improving the throughput and scalability of expressed protein ligation via flow chemistry - Lucas Kambanis
• Assessing the antifungal activity of Latarcin-1 derived peptide LDP-NLS against Mucorales. - Gagan Kaur
• Manoeuvring in silico approach in designing a novel marine-derived peptide - Prasanjeet Kaur
• Development of a Novel Cytosolic Delivery Peptide with Attenuated Cytotoxicity and Enhanced Endosomal Uptake   - Yoshimasa Kawaguchi
• Characterisation of a short, glycosylated peptide from yeast; Seripauperin 5 - Zan Kelly
• The ant venom peptide, Ta3a, modulates the biophysical properties of voltage-gated sodium channels - Angelo Keramidas
• Isolation and characterization of cyclotides from Viola communis and comparative transcriptome analysis with Viola odorata - Negin Khatibi
• Protein tryptophan modification enabled by using S-protected cysteine sulfoxide under mild acid conditions - Daishiro Kobayashi
• Salty peptide derived from the sweetness loops of sweet-tasting protein - Kwang-Hoon Kong
• Conformation control of bicyclic peptides using 1,2,3-TBMB as a linker - Haritha Krishna Sudhakar
• New semi-synthetic technologies for accessing post-translationally modified proteins - Sameer S. Kulkarni
• Marrying Activity with Permeability. Towards Orally Bioavailable Somatostatin Peptide Therapeutics - Travis Lay
• PEP27-2, a Potent Antimicrobial Cell-Penetrating Peptide, Reduces Skin Abscess Formation during Staphylococcus aureus Infections in Mouse When Used in Combination with Antibiotics - Hayoung Lee
• Comparative Antimicrobial Activity of Hp1404 Peptide and Its Analogs against Acinetobacter baumannii. - Yeeun Lee
• Chemical modification of antimicrobial peptides - Wenyi Li
• Rational design of membrane active antimicrobials against multi-drug resistant Gram negative bacteria - Kai Yi Eldeen Lim
• Unraveling the pathology and propagation mechanism of phosphorylation-regulated α-synuclein in α-synucleinopathies - Yeh-Jun Lim
• Lipidation of Kv1.3 blocking peptide HsTX1[R14A] alters its pharmacokinetics and biodistribution to target tissues - Lihuan (Ada) Lin
• An Aza-Michael Route to Quaternary Ammonium Compounds and its Application to Antimicrobial Peptides - Rolland Lin
• Screpyard: an online resource for disulfide-stabilised tandem repeat peptides - Junyu Liu
• Membrane-Active Bakuchiol Based Peptidomimetics as Effective Broad-Spectrum Antibacterial Agents - Shouping Liu
• Synthesis of Mandarin Fish Ranavirus (MFRV) - viral insulin/IGF-like peptide - Marta Lubos
• Regulation of liquid-liquid phase separation with focus on post-translational modifications - Yunyi Luo
• Prediction of membrane permeation by drugs - Weishuai Ma
• Electrochemical Modification of Polypeptides at Selenocysteine - Angus Mackay
• Development of the novel pesticides removing recombinant bacterial strain by displaying the specific binding peptide - Soonho Hong
• In silico identification of key residues in ShKT peptides responsible for modulating dynamics and affinity for the voltage-gated potassium channel Kv1.3 - Viktor Prypoten