Tuesday, 17th October International Peptide Symposium 2023

• Greener production approaches for therapeutic peptides - David J Craik
• Biosynthesis and bioengineering of peptidyl epoxyketone proteasome inhibitors - Gregory L Challis
• New Selenium-Mediated Methods for Protein Synthesis and Modification - Emma E Watson
• Structural Subtleties of Protein Posttranslational Modifications - Anne C Conibear
• Sugars & Proteins  - Ben Davis

• A peptide complement inhibitor inhibits neuroinflammation and neurodegeneration in Parkinson’s disease - Trent M Woodruff
• It’s what’s inside that counts: Developing peptide-lipid conjugates for the control of NK₁R signalling from intracellular compartments - Nicholas Veldhuis
• New insights into CGRP receptors in migraine - Debbie L Hay
• A LASEREDD Focus: Lentiviral-Driven Directed Evolution of Optimised G Protein-Coupled Receptors for Biologics Discovery. - Daniel J Scott
• A story of translating peptide treatment for neurodegenerative diseases - Elizabeth Coulson
• Biased agonism at the GLP-1 receptor: from structure to animal models of disease - Denise Wootten

Nik Veldhuis is sponsored by

• Multiplex substrate profiling by mass spectrometry (MSP-MS): A versatile peptide digestion technique for the study of proteases - Anthony J O'Donoghue
• Proteomic identification of SARS-CoV-2 3CL^pro P6—P6' active site specificity to inform optimization of superior quenched fluorescent peptide substrates   - Chris Overall
• Defensin-lipid interactions in membrane targeting: novel insights into mechanisms of action and therapeutic potential - Mark D Hulett
• Fluorescent probes derived from antimicrobial peptides: tools for discovery and diagnostics - Mark Blaskovich
• In silico optimization of antimicrobial peptide enables the development of bioinspired products. - Octávio L Franco
• Aminoacylation of Indole Diterpenes by Cluster-Specific Monomodular NRPS-like Enzymes - Emily J Parker

Research has shown a strong positive correlation between diversity and innovation and the ability for groups to develop creative solutions. It has also been shown that without inclusion, the power of diversity cannot be successfully harnessed. Although the research is clear, there are many who struggle with understanding and unleashing the power of diversity. One of the keys to fully leveraging the potential in diversity is inclusive leadership. In this talk, I will address aspects of intersectional diversity and how to nurture an inclusive mind-set so that we can collectively shape a future where everyone has equal opportunity to pursue their passions and excel in their chosen path.

Dr. Phaedria Marie St.Hilaire

CEO and Chief Consultant at Phaedria Marie Consulting

Business Angel Investor at Purple Orchid

Dominican born Science Business Leader with over 20 years experience in the Pharmaceutical and Biotech industries and a passion for people development and making change. She has a proven track record of inspiring and driving cross functional, multicultural teams to deliver results from her leadership positions at global companies like Carlsberg and Novo Nordisk; and from her non-profit organization, ProWoc (Professional Women of Colour Network).

Phaedria is passionate about diversity, inclusion and belonging, and changing the gender and race narrative. She strives to incorporate these principles in an inclusive leadership practice and her everyday professional and personal undertakings. She believes in empowerment of self and others, continuous learning, self-reflection, and reinvention and is also Mentor and Certified Executive Coach from Henley Business School. She is a Business Angel Investor and was recently selected as one of the 10 most inspiring Business Angels in Denmark.

In addition to a Ph.D. in Chemistry, Phaedria holds a degree in Business Administration from Copenhagen Business School and is a skilled project manager with a LEAN 3 Star/6 Sigma Black belt certification. She is also certified to serve on Boards from Niels Brock Business School and is currently a member of Crossing Borders Executive Board. Phaedria has over 45 publications and 5+ patent applications within Chemistry and Biochemistry. 

Phaedria is a sought-after public speaker and storyteller, mainly on the topics of Inclusive Leadership, Gender Equality, DEIB, and on Career Reinvention and Transformations from the perspective as a woman in STEM.

• Glycolipid-Peptide Conjugate Vaccines Chemically Programmed for Nanoparticle Self-Assembly - Sarah L Draper
• Inducing potent and protective immunity against SARS-CoV-2 with intranasally administered lipopeptide vaccines targeting TLR-2 - Joshua Maxwell
• Role of Ser/Thr phosphatase PPM1D on Neutrophil subset polarization - Rui Kamada
• Unveiling hidden functions of anti-inflammatory dietary electrophiles in platelets through integrated phenotypic and chemoproteomic approaches - Xuyu Liu
• Synthetic, peptide-based, self-adjuvanting vaccines based on the cancer-related MUC1 antigen, a T-helper epitope and a saponin immunoadjuvant - Alberto Fernandez-Tejada

• Development of cell adhesive peptide-polysacchride matrices for biomaterial - Motoyoshi Nomizu
• Rational design of potent ultrashort antimicrobial peptides with programmable assembly into nanostructured hydrogels - Celine Valery
• Engineering of microtubules by Tau-derived peptide-fused proteins - Hiroshi Inaba
• The membrane sensing peptide toolbox in extracellular vesicles research - Alessandro Gori
• Advancing protein-protein interaction inhibitor design using minimal self-standing peptide mimetics based on an oligo(N-methylalanine) framework - Shinsuke Sando

• Protein-Protein Interaction Inhibitors as Tools in Chemical Biology - Olalla Vázquez
• In vivo reconstitution of signal peptides for biosensing applications - Youngeun Kwon
• Switching prenyl donor specificities in cyanobactin prenyltransferases to access unprecedent prenylation modes - Yuki Goto
• Peptide Asparaginyl Ligase: A Gift from Plants for Protein Engineering - Xinya Hemu
• Structure and activity of backbone-modified class B1 GPCR agonists - Brian P Cary
• Molecular tools to study the oxytocin receptor system - Monika Perisic
• Covalent ligands on the rise: Development of ‘furan warhead’- equipped nanobodies - Laure Tack
• Silencing oncogenic signalling with Transcription Block Survival assay-derived peptides - Andrew Brennan
• In-silico Design and Discovery of Small Molecule Hits Targeting the Neurotensin Receptor 2 (NTS2) Using a Rational Peptide-to-Small Molecule Approach - Michael Desgagné

• Novel functional polypeptides "r-Peptides" encoded by latent ORFs in bacterial ribosomal RNAs. - Kazuyasu Sakaguchi
• A novel non-covalent stapling strategy for generating α-helical peptidomimetics - Akhter Hossain
• Design of next-generation peptide ligands for the κ-opioid receptor - Christian W Gruber
• Anti-SARS-CoV-2 Agents Inspired from HIV Researches - Hirokazu Tamamura
• Generation of neurokinin receptor ligands with specialized signaling properties via nanobody conjugation - Nayara Braga Emidio
• Stretching Peptides: Diyne-Mediated Access to Extended Structures - Zoë Adams
• Probing the limits of machine learning-guided peptide discovery - Fabien Plisson
• Development of cyclic peptide modulators of lymphocyte migration - Jasmin Gattringer
• New effective peptide-porphyrin conjugates against Zika and other brain-targeting viruses - Toni Todorovski

Explore the vibrant city and enjoy some of Brisbane's local hospitality.

Includes Rapid Fire Poster Presentations

• Structure and activity of backbone-modified class B1 GPCR agonists - Brian P Cary
• Molecular tools to study the oxytocin receptor system - Monika Perisic
• Covalent ligands on the rise: Development of ‘furan warhead’- equipped nanobodies - Laure Tack
• Silencing oncogenic signalling with Transcription Block Survival assay-derived peptides - Andrew Brennan
• In-silico Design and Discovery of Small Molecule Hits Targeting the Neurotensin Receptor 2 (NTS2) Using a Rational Peptide-to-Small Molecule Approach - Michael Desgagné

• Generation of neurokinin receptor ligands with specialized signaling properties via nanobody conjugation - Nayara Braga Emidio
• Stretching Peptides: Diyne-Mediated Access to Extended Structures - Zoë Adams
• Probing the limits of machine learning-guided peptide discovery - Fabien Plisson
• Development of cyclic peptide modulators of lymphocyte migration - Jasmin Gattringer
• New effective peptide-porphyrin conjugates against Zika and other brain-targeting viruses - Toni Todorovski

• Development of Peptide-based Ratiometric Fluorescent Probe for Sensing Heparan sulfate and Heparin in aqueous solutions at physiological pH and Quantitative Detection of Heparan Sulfate in Live Cells. - Sumita Subedi
• Selective detection of methylmercury over mercury using fluorescent peptidyl probes by replacing dimethylamino group with cyclic amino rings in micelle system. - Hyojin Park
• A Study on Copper(I)-catalyzed Azide-Alkyne Cycloaddtion(CuAAC) Click Reaction in different Conditions Using Ratiometric Fluorescent Probe. - Myeonggeun park
• Synthesis and in vivo evaluation of a synthetic anti-cocaine nanovaccine - Harrison Y.R. Madge
• Impact of peptide length on in vivo hydrogel stability and sustained drug release - Morgane Mannes
• α-amylase (AA) and dipeptidyl peptidase IV (DPP-IV) inhibitory bioactive peptides generated from young and mature soybean protein isolates: Characterization and identification - Maqsood Maqsood
• Novel Peptides as Selective Affinity Labels of the AT2R - Ivan O. Maslov
• Proteolytic resistant antimicrobial peptide against pseudomonas aeruginosa keratitis - Venkatesh Mayandi
• Antimicrobial Frog Peptide-based Combination Therapy against Mycobacterium tuberculosis - Anjana Peethambaran Menon
• Targeting mucosal gastrointestinal biofilms with antimicrobial peptides - Michael Michael
• Vimentin and citrullinated-vimentin in the crosstalk during THP-1 monocyte cell line differentiation and inflammasome activation. - Agata Mikolajczyk-Martinez
• Ribosomal synthesis of macrocyclic D/L-α/β/γ-hybrid peptide libraries for discovery of IFNGR1 inhibitors - Takashi Miura
• Combinational use of CD4 mimic with other anti-HIV agents and development of these hybrid molecules - Yutaro Miura
• Bioinspired peptide stapling - Richard Morewood
• Computer-Aided Development of Antiviral PROTACs to Target and Degrade SARS-CoV-2 PL-Protease - Tobias D Morris
• Towards structural determination of Relaxin receptor [RXFP1] - Tiffany (Theingi) Myint
• Lipid Derivatisation of Polymyxin B Nonapeptide via a Chemoselective Thia-Michael Approach - Tae Ung Na
• Understanding IRAP inhibition using diverse substrates, inhibitors and mutagenesis - Rie Nakao
• 2,5-Diketopiperazine Formation Facilitated by γ-Substituted Prolines for Direct Synthesis of Tag-Attached Peptide Thioester - Koki Nakatsu
• Late-Stage Modification of Peptides via Strain Release of [1.1.1]Propellane - Philippe Nashar
• Design and rational engineering of a Batroxicidin peptide derivative for anti-cancer therapy - Malay Ranjan Nayak
• Discovering Novel Natural Products to Combat Antibiotic Resistant Pathogens - Negero Negeri
• Detection of peptide-Keap1 interaction and selection of Keap1-binding peptides using engineered split intein and kanamycin kinase - Kana Nobusawa
• Progress towards the total synthesis of lexapeptide - Michael Noden
• Broadly Applicable Synthetic Method for N-Alkyl-Rich Drug-like Cyclic Peptides - Kenichi Nomura
• Purification and Identification of the myostatin inhibitory peptides from mealworm (Tenebrio molitor larvae) protein hydrolysate in C2C12 cells - Eunyoung Oh
• Anti-biofilm and anti-inflammatory effects of Lycosin-II isolated from spiders against multi-drug resistant bacteria. - JunHee Oh
• Protecting Group-Minimized Peptide Synthesis Using Peptide Thioacid - Kounosuke Oisaki
• Small Molecules with Cyclic Dipeptide and Gallic Acid Moieties Ameliorate Ferroptosis and Amyloid Toxicity Associated with Alzheimer’s Disease - Dikshaa Padhi
• Antiplasmodial peptide–drug conjugates incorporating a platelet-derived cell-penetrating peptide - Isabella Palombi
• Total Synthesis, Structure-Activity Relationship Study, Bioactivity and Nephrotoxicity Evaluation of the Novel Cyclic Lipodepsipeptide Brevicidine B - Dennise Palpal-latoc
• Bactericidal activities and Action mechanism of the Novel Antimicrobial Peptide Hylin a1 and its analog peptides against Acinetobacter baumannii infection - Hee Joo Park
• Design and synthesis of asymmetric covalently tethered cyclic peptide nanotubes  - William Parsons
• Acid-stable ester linkers for the synthesis of immobilized peptides - Jan Pícha
• Auditing structural bias in machine learning-guided antimicrobial peptide discovery - Fabien Plisson
• Machine learning-guided discovery of antifungal peptides from hymenopteran venoms - Fabien Plisson
• Mitigating the structural bias in discovering membrane-active antimicrobial peptides using inverse protein folding - Fabien Plisson
• Exploring the structure-activity landscape of non-canonical peptides with MAP4 fingerprinting - Fabien Plisson
• Structural effects in aza-peptide bond formation reaction - Anu Ploom
• Selectivity of aqueous N-thiophosphorylation of peptides - Robyn E Poulton
• Photocontrollable probes for the investigation of neuropeptide signalling and emotional memory - Konstantin Raabe
• Developing novel inhibitors for survivin anti-apoptotic function - Saharnaz Rafiee
• An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides - Nishant Raj
• Design and Preparation of Atactic Artificial L/D-Proteolytic Enzymes - Mads Liep Ramsing
• Targeting the incorporation of hydroxy-acids in NRPS biosynthesis - Minuri Ratnayake
• Reducing the Bottlenecks in the Drug Discovery Peptide Workflow - Cedric Rentier
• Influence of D-arg and D-lys on the structure and antibacterial activities of computer-made peptides - Samilla B Rezende
• Mending achy breaky hearts: cyclic peptide TropL01 as therapeutic for heart failure  - Daniela Rojas-Azofeifa
• Selectively cleavable protecting groups for the epsilon-amino group of lysine - Karin Rustler
• Exploration of the peroxidase-like activity of Cytochrome P450 CYP121 from Mycobacterium tuberculosis - Hannah Ryan
• Photoaffinity labelling for the elucidation of mycocyclosin target protein(s) - Hannah Ryan
• How cell penetrating peptides escape endosomes? - Himaya S.W.A.
• Ultrashort histidine-based lipopeptides show more potent activities than ampicillin against Escherichia coli and Staphylococcus aureus - Remmer L. Salas
• Design, characterization and evaluation of a protide with therapeutic potential for control of fish farming diseases. - Paula Santana
• Proteomic Profiling and Antimicrobial Potential of Epidermal Mucus from Chilean Aquaculture Fish Species - Paula Santana
• Protease-activated receptor 2 is activated by peptides that modulate doxorubicin-induced apoptosis in cancer cells - Himani Deepak Shah
• Hymenopteran venom bradykinin-like peptides mimic vertebrate bradykinin peptide hormones to cause pain and deter predators. - Naiqi Shi
• Design and evaluation of a novel cell penetrating peptide for enhanced corneal wound healing - Mayank Sinha
• Peptide-based PROTAC specific degradation of endogenous Tau proteins - Yue Su
• Stimuli-Responsive Coiled Coil-Based Nanostructures - Esteban Suarez Picado
• Virus-directed enzyme prodrug therapy - Polly Sun
• Superfast Desulfurization for Protein Chemical Synthesis and Modification - Zhenquan Sun
• A new hope for the peptide antibiotic ramoplanin - Julien Tailhades
• Detection of Cytoplasmic Peptide:N-Glycanase Activity inside Cells Using Split Inteins and NanoLuc Luciferase - Tsuyoshi Takahashi
• Chemically Modified Amino Acids as Site-Specific ¹⁹F-NMR Probes in Proteins - Yi Jiun Tan
• Oral Hepcidin Peptidomimetics – Potent Pharmacodynamic Activities in Rodents and Non-Human Primates - Fei Tang
• Intracellular application of an asparaginyl endopeptidase for producing recombinant head-to-tail cyclic proteins - T. M. Simon Tang
• Designing cyclic peptide FXIIa inhibitors by optimising loop 6 in a cyclotide scaffold - Sixin Tian
• Synthesis and Biological Evaluations of Teixobactin Analogues against Gram-positive Bacteria and Biofilms - Tsz Ying Teresa To
• Circular peptides as a new class of ligands to modulate cannabinoid type 2 receptor signaling - Natasa Tomasevic
• Spider beta-hairpin peptide engineered to target protein:protein interactions, reach the cytosol, and kill cancer cells - Sonia Troeira Henriques
• Investigating the inhibitory property of double mutated hCT on hCT fibrillization via the relevant peptide fragments - Ling-Hsien Tu
• Multiply-Entangled De Novo Proteins - Dattatraya Uttam Ukale
• Biocompatible peptide bicyclisation using dicyanopyridine amino acids - Sven Ullrich
• Novel peptide therapeutics for Alzheimer’s disease - Dorothy Wai
• Detection of peptide-MDM2 interactions and selection of MDM2-binding peptides using engineered split intein and kanamycin kinase - Yutaro Watanabe
• Towards Genetic Encoding of 4-Azatryptophan and 6-Azatryptophan - Adarshi P. Welegedara
• Harnessing Thioesterase Domains for Probing Antibiotic Modifications - Danella West
• Total Synthesis of Complex Peptide Natural Products - Andrew M White
• The saltwater crocodile defensin CpoBD13 is a novel pH‑sensing antifungal peptide - Scott Williams
• Synthetic C5a peptide or anaphylatoxin C5a protein induce Rab5a-C5aR1 trafficking, chemotaxis and chemokine secretion in human macrophages - Kai-Chen Wu
• Computational design of α-conotoxins to target specific nicotinic acetylcholine receptor subtypes. - Xiaosa Wu
• Palladium-Catalysed Lage-Stage C–H Arylation of Peptides - Yuezhou Wu
• Fungal oxepine natural product: biosynthesis and engineering - Coco Xie
• RGDX₁X₂ motif regulates integrin αvβ5-mediated cell adhesion - Yuji Yamada
• Staple-biased phage display for targeting ALT-positive cancers - Jackie Tsz Ki Yau
• Lycosin-II Exhibits Antifungal Activity and Inhibits Dual-Species Biofilm by Candida albicans and Staphylococcus aureus - Hogeun Yoon
• Design of peptide-based probes for detecting phospholipid head group - Jingyao You
• Incorporating alkylthioaryl linkage in macrocyclic peptidomimetic design: Discovery of novel melanocortin ligands for melanoma imaging and therapy - Wenxiao K Yue
• Targeting inflammation using genetic reprogramming in mRNA display - Belinda Zhang
• Enhancing peptide-based vaccine immunogenicity: role of cyclic decapeptide as a multivalent scaffold - Jiahui JZ Zhang
• Developing a PCSK9 degrader for lowering cholesterol - Yuhui Zhang
• Development of bifunctional antibody with immune checkpoint inhibitory effect using Lasso-grafting - Jinxuan ZHAO
• Structural studies of the mechanism of voltage-sensing in voltage-gated ion channels using cyclised nanodiscs - Yifei Zhu
• Elucidating Binding Pathway of Peptide Ligands to the Neurotensin 1 Receptor: from Solution Phase to Final Binding Conformation - Herodion Hartono