10 min Rapid Fire International Peptide Symposium 2023

Biosynthesis of bicyclic depsipeptide histone deacetylase inhibitors (#46)

Xinyun Jian 1 2 3 4 , Jinlian Zhao 1 , Edward  Marschall 2 3 , Emmanuel L.C. de Los Santos 1 4 , Douglas M. Roberts 1 4 , Lona Alkhalaf 1 4 , Max J. Cryle 2 3 , Greg L. Challis 1 2 3 4
  1. Chemistry Department, University of Warwick, Coventry, United Kingdom
  2. Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
  3. ARC Centre of Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton, Victoria, Australia
  4. Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, United Kingdom
Publish consent withheld
  1. Shigematsu, N. et al. FR901228, a novel antitumor bicyclic depsipeptide produced by chromobacterium violaceum no. 968. II. Structure determination. J. Antibiot. (Tokyo). 47, 311–314 (1994).
  2. Masuoka, Y. et al. Spiruchostatins A and B, novel gene expression-enhancing substances produced by Pseudomonas sp. Tetrahedron Lett. 42, 41–44 (2001).
  3. Biggins, J. B. et al. Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis. Org. Lett. 13, 1536–9 (2011).
  4. Masakuni O. et al. 1991. JP 3141296.
  5. Cheng, Y.-Q. et al. Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum No. 968. Appl. Environ. Microbiol. 73, 3460–9 (2007).
  6. Potharla, V. Y. et al. Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator. J. Ind. Microbiol. Biotechnol. 41, 1457–1465 (2014).