Given the progressively aging populations in recent years, the number of dementia patients has been increasing. In some countries one in seven people aged 65 or older have dementia, and the number is expected to increase further in the future. Measures to address dementia have become a social issue and consequently there is a need to establish methods for early detection, treatment, and prevention. Though a variety of diseases can cause dementia, Alzheimer’s dementia accounts for the highest number of patients, accounting for about 60 % of the total. This presentation will give an overview of a validated non-invasive test using automated immunoprecipitation and simple MALDI TOF analysis.